In the United States are testing a drug that causes cancer cells to self-destruct

Date:

2017-11-29 19:00:05

Views:

3204

Rating:

1Like 0Dislike

Share:

In the United States are testing a drug that causes cancer cells to self-destruct Source:

According to the publication Sciense Daily, a group of scientists from the University of Illinois is embarking on clinical trials of an anticancer drug of new type, which causes cancer cells to self-destruct. Moreover, animal studies have yielded success, and now it is time to test the effectiveness of the drug in the treatment of people.

In a new series of experiments will involve patients suffering from pleomorphic glioblastoma and anaplastic astrocytoma — the two most dangerous forms of cancer that are localized predominantly in the brain, its membrane of the vessels. An experimental drug called PAC-1, a feature of which is that he is able to easily pass through the blood-brain barrier (a structure similar to a filter, selectively transmissive to the brain of various substances). The effect of PAC-1, which will be tested in conjunction with temosolomida (the drug of choice in chemotherapy of brain cancer). The tests on the enzyme procaspase-3. It is present in cancer cells and is inactive, but activation of this enzyme leads to cell death. She's just starting to break down from the inside. Cancer cells have learned to suppress the activity of this enzyme, but PAC-1 "turns on" the gene and causes the tumor to "kill herself". And the drug that matter, does not affect healthy cells.

As mentioned earlier, a substance successfully tested in culture of human cells, and on pet dogs with naturally occurring osteosarcoma, lymphoma, and glioma. The trials revealed that the combination of PAC-1 with chemotherapeutic drugs provides the opportunity to significantly reduce the size of tumors and even get rid of them. In addition, all previous studies revealed virtually no complications (including Central nervous system), except for a small gastrointestinal disorders.

Recommended

The coronavirus has mutated into 30 new strains

The coronavirus has mutated into 30 new strains

While coronavirus Apocalypse slowly but inevitably becomes routine, the virus SARS-CoV-2 continues to evolve. And, unfortunately, he was good at it. Writes , with reference to the South China Morning Post reports that new studies show that the virus ...

In the United States recognized that the ventilator dies 88% of patients with coronavirus

In the United States recognized that the ventilator dies 88% of patients with coronavirus

When the world is raging coronavirus that causes pneumonia and kills people, the only solution is intensive care. If this is not done, the victims will be very much. Today for severe patients there is only one solution — connected to the appara...

Can a transfusion of blood plasma to cure the coronavirus?

Can a transfusion of blood plasma to cure the coronavirus?

Typically, vaccination involves the introduction into the organism of the weakened or killed microorganisms (viruses) designed to create a strong immunity to possible future infectious diseases — that is, for selection of antibodies. But what i...

Comments (0)

This article has no comment, be the first!

Add comment

Related News

The Chinese developed a 3D bio-printer for mass production of human tissue

The Chinese developed a 3D bio-printer for mass production of human tissue

Chinese scientists have developed a 3D bio-printer able to print human tissue. With the latest developments it is planned to mass-produce skin, cartilage and tissues of the liver. «Mass production of medical materials, high...

Created synthetic analog of the cellular receptor

Created synthetic analog of the cellular receptor

As you know, all the metabolic processes in our body occur at the cellular level. Special structures (receptors) on the surface of cells and cellular elements that regulate membrane permeability to certain substances that trigger ...

The us military has learned to control the mood of the people using the neural chips

The us military has learned to control the mood of the people using the neural chips

according to the journal Nature, the research Agency DARPA funded the development of a system for automatically controlling the person's mood, which in real-time scans of brain activity and, if necessary, eliminates the "unwanted ...

Conducted the first operation using 3D printing

Conducted the first operation using 3D printing

On the application of three-dimensional printing in medical practice talking for a long time, and on this subject, conducted a lot of experimental studies. And here, according to the editors of the portal Plus China, at the hospit...

When we can live two hundred, three hundred, four hundred years and more?

When we can live two hundred, three hundred, four hundred years and more?

Live a hundred years — not so difficult as to prove the individual. In theory, we could live for centuries. On this work, many scientists dream, but so far not much success. Do you have someone your own age a chance to live hundre...

Scientists have restored paralyzed rats the ability to walk

Scientists have restored paralyzed rats the ability to walk

according to the newspaper EurekAlert, a group of scientists from the Israel Institute of technology first succeeded with the help of stem cell therapy to paralyzed rats regain the ability to walk and ability to feel your limbs. I...

To hack the human brain: a Grand plan of Brian Johnson

To hack the human brain: a Grand plan of Brian Johnson

In a typical hospital in Los Angeles, a young woman named Lauren Dickerson waits for his chance to make history. She was 25 years old, and she's an assistant high school teacher, with kind eyes and computer cables that look like f...

In Volgograd have developed the strongest pain reliever, does not cause addiction

In Volgograd have developed the strongest pain reliever, does not cause addiction

ordinary painkillers usually have flaws. Strong, for example, often are addictive, and therefore assigned, in extreme cases, small doses. But harmful and addictive painkillers may soon be in the past — scientists of the Volg...

Heavy metal from meteorites have been able to kill the cancer cells

Heavy metal from meteorites have been able to kill the cancer cells

Iridium is the second-density metal in the world — can kill cancer cells, imbuing them with a deadly version of the oxygen, leaving healthy tissue intact. First discovered in 1803, metal got its name from the Latin "rainbow". Heav...

Sergio Canavero said the successful transplant of the head of the corpse...

Sergio Canavero said the successful transplant of the head of the corpse...

Teddy bears, there is one nice feature: if your dog pulls the head of this, you can sew it in place. But unless you call his achievement "wild success"? No, you say "I fixed your dead toy." But Sergio Canavero all the way. just ye...

The neural network puts diagnoses better than doctors

The neural network puts diagnoses better than doctors

a Group of scientists from Stanford University have developed a neural network which based on several x-ray can diagnose pneumonia, and it makes it no worse than practitioners-radiologists. To create an algorithm, scientists have...

Whether red wine rejuvenates?

Whether red wine rejuvenates?

By the middle of this century 60 years for the first time in history exceeded the number of 18-year-old. Seemingly good news, but aging, people become frail, sick and dependent. Healthy ageing — to the benefit of both you and the ...

In the USA man first made a vaccine against cancer

In the USA man first made a vaccine against cancer

Create a cure for cancer will be a huge breakthrough for mankind, but the disease is known, it is much better to prevent than to cure. And recently, as reported by Bloomberg, a team of scientists from the United States first teste...

The first time scientists have directly edited the genome inside a living human

The first time scientists have directly edited the genome inside a living human

Employees Benioff Children's hospital (UCSF Benioff Children's Hospital) in Auckland for the first time in the United States tested a technique for genome editing directly in the body of a living person, and not by introducing him...

The Chinese AI has got a doctor's licence

The Chinese AI has got a doctor's licence

iFlyTek, a Chinese company in Shenzhen working on his artificial intelligence for four years. The program AI to better prepare for the exams in local medical school and have successfully passed all the tests. The results of the ex...

In the United States to establish the centre transplant pig heart man

In the United States to establish the centre transplant pig heart man

the First center xenotransplantation research in the USA very soon. His tasks will include the study of methods of transplanting pigs hearts of man. To do this, United Therapeutics has invested in a new organization 24 million dol...

What Alzheimer's does to the brain?

What Alzheimer's does to the brain?

about 50 million people worldwide live with Alzheimer's disease. And with aging populations in many countries, the numbers suffering from this disease are steadily increasing. We know that Alzheimer's is caused by problems in the ...

Eternal life may be mathematically impossible

Eternal life may be mathematically impossible

in 2016, when the FDA turned on the green light for clinical trials of metmorfin — a drug that increases life expectancy by 40% in animal models, it became clear that a paradigm shift occurs in our attitude to aging and life expec...

Russian scientists have created an artificial kidney new type

Russian scientists have created an artificial kidney new type

There are diseases that require a transplant immediately because of the huge health hazards, but often people like this need to wait for several months or even years. And then come to the aid of treatments. For example, if the kid...

Scientists won one of the deadliest and incurable diseases

Scientists won one of the deadliest and incurable diseases

There is a very rare genetic disease — epidermolysis bullosa characterized by blistering and erosions on skin and mucous membranes, skin fragility and its sensitivity to minor mechanical trauma (let's just say it's better th...