Discovered a molecule that helps to deal with obesity without exhausting diets
Source:Perhaps very soon it will be possible to lose weight without dieting
About the dangers of excess weight has been written a variety of materials, including . And scientists from around the world, in turn, continue to seek funds to combat the excess weight. And that logical approach experts often is the development of new methods that are not associated with exercise or different diets. So, for example, recently opened the molecule, which allows you to lose those extra pounds without starving and exercise.
How to lose weight without dieting
According to the newspaper New Atlas, researchers from the University of Texas in the course of studying the molecular mechanisms that lead to weight gain, found that a small molecule called miR-26 slows down the accumulation of fat in adipose tissue and thereby may be used in the treatment of obesity.
It is Worth noting that the molecule miR-26 belongs to the class of so-called micro-RNAS. By themselves micro-RNA in our body play a very important role: they regulate gene expression. In this case, miR-26 , that affect insulin sensitivity and, most interestingly, control the accumulation of adipose tissue. In the course of further research, scientists began to look for the target, which operates miR-26. That is needed to find the gene, which triggers the accumulation of fat. And it was FBXL19 gene.
Then the fun began. Scientists have found that if the detected gene to block the growth of fat tissue. On the contrary, if gene «work hard», fat is deposited with much greater speed. After this discovery, the experts used the editor CRISPR genome and it has been edited laboratory mice so that their bodies do not play any miR-26. Another group of animals, on the contrary, caused excessive production of the molecule. The most significant experiments with the use of the editor of the genome we regularly covered on our website. So rekomenuem , so do not miss it.
Leading the authors who discovered «magic» molecules — Dr. Joshua Mendell and Dr. Asha Acharya
As a result of experience rodents from the first group at the age of puberty began to accumulate adipose tissue, and in the end, after some time the content . But animals of the second group maintained a normal weight. The average weight of the mice with the deactivated molecule miR-26 was 40% than that of rodents that have had this molecule in excess. It is worth to mention that all the mice for the experiment were fed fatty, high carbohydrate food, and laboratory animals with normal weight had not only a normal body weight, but low blood sugar levels.
Also interesting is this: no side effects from the increase in expression of miR-26 in the body of mice was found. Now scientists are trying to develop methods of influence on the production of molecules of miR-26 in the human body. After that it is planned to start the phase of testing the new methodologies on people.
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